منابع مشابه
Mechanisms of hypothermic neuroprotection.
Prolonged, moderate cerebral hypothermia initiated within a few hours after severe hypoxia-ischemia and continued until resolution of the acute phase of delayed cell death can reduce acute brain injury and improve long-term behavioral recovery in term infants and in adults after cardiac arrest. The specific mechanisms of hypothermic neuroprotection remain unclear, in part because hypothermia su...
متن کاملUpdate on Techniques for Neuroprotection during Hypothermic Arrest
Surgical repair of the ascending aorta and aortic arch that employs cardiopulmonary bypass (CPB), often with the use of deep hypothermic circulatory arrest (DHCA), allows for lifesaving therapy. In doing so, however, it also represents a unique injury paradigm leading to derangements in numerous homeostatic pathways. Organ injury, most notably cerebral injury, may result as a consequence of the...
متن کاملMelatonin augments hypothermic neuroprotection in a perinatal asphyxia model.
Despite treatment with therapeutic hypothermia, almost 50% of infants with neonatal encephalopathy still have adverse outcomes. Additional treatments are required to maximize neuroprotection. Melatonin is a naturally occurring hormone involved in physiological processes that also has neuroprotective actions against hypoxic-ischaemic brain injury in animal models. The objective of this study was...
متن کاملPre, intra and post-ischemic hypothermic neuroprotection in temporary focal cerebral ischemia in rats: morphometric analysis.
OBJECTIVE To evaluate the neuroprotection of mild hypothermia, applied in different moments, in temporary focal cerebral ischemia in rats. METHODS Rats was divided into Control (C), Sham (S), Ischemic-control(IC), Pre-ischemic Hypothermia (IH1), Intra-ischemic Hypothermia (IH2), and Post-ischemic Hypothermia (IH3) groups. Morphometry was performed using the KS400 software (Carl Zeiss®) in cor...
متن کاملErythromycin induced neuroprotection during prolonged deep hypothermic circulatory arrest in an acute porcine model
Methods Piglets were treated with erythromycin (25 mg/kg, iv) (n = 8) or vehicle (n = 6) and subjected to 75 minutes of DHCA at 18°C, 12 hours after pretreatment. Three served as normal controls. After gradual rewarming, treatment animals were sacrificed and brains were perfusion-fixed and cryopreserved. Motor cortex was dissected from the left hemisphere and paraffin embedded for histologic st...
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ژورنال
عنوان ژورنال: Neurotherapeutics
سال: 2006
ISSN: 1933-7213,1878-7479
DOI: 10.1007/bf03207046